2017 MARKET UPDATE:
Sony shelved one movie project, and announced Venom as their 2018 superhero movie release. Prices, predictably enough, went berserk overnight, as speculators and investors piled into this already hot book.
While Stan Lee continues to astound observers with his longevity and ability to continue raking in cash for signing comic books, eventually he WILL expire. Copies of ASM 300 signed by Stan Lee in a Signature Series holder are particularly popular when combined with Todd McFarlane's signature.
Venom is one of the hottest properties in the Spider-Man universe right now, and it's understandable that his first full appearance is on the Hot 100 list.
Movie rumors won't leave this character alone. Sony and Marvel have agreed to work together on the second Spider-Man movie reboot, and along with Carnage, and the various Symbiote (black costume) first appearances, there are few affordable books we could recommend more highly.
Other Spider-Man villains which appear in the Hot 100:
Amazing Spider-Man #2 (1st Vulture)
Amazing Spider-Man #14 (1st Green Goblin)
Amazing Spider-Man #101 (1st Morbius)
Amazing Spider-Man #50 (1st Kingpin)
Amazing Spider-Man #129 (1st Punisher)
Stick to a CGC 9.8 with white pages, unless you can afford a 9.9 and one comes to market.
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